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Clinical Summaries

Read the clinical summaries below to see how treatment delays for patients can lead to adverse outcomes.1-4

Non-shockable cardiac arrest1

Time to Administration of Epinephrine and Outcome After In-Hospital Cardiac Arrest With Non-shockable Rhythms

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Acute severe hemorrhage2

Effect of Treatment Delay on the Effectiveness and Safety of Antifibrinolytics in Acute Severe Hemorrhage

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Sepsis3

Empiric Antibiotic Treatment Reduces Mortality in Severe Sepsis and Septic Shock from the First Hour

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Stroke4

Timeliness of Tissue-Type Plasminogen Activator Therapy in Acute Ischemic Stroke

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Read the clinical summaries below to see how Intraosseous Access (IO) compares to other vascular access devices.

IO vs. CVC5

Intraosseous Versus Central Venous Catheter Utilization and Performance During Inpatient Medical Emergencies

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IO vs. CVC vs. PIV6

Moving the Needle on Time to Resuscitation

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IO vs. IV7

Efficacy of Intraosseous Access for Trauma Resuscitation: A Systematic Review and Meta‑analysis

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Additional Studies

View our full bibliography

References:

  1. Donnino MW, Salciccioli JD, Howell MD, et al. BMJ. 2014;348:g3028.
  2. Gayet-Ageron A, Prieto-Merino D, Ker K, et al. Lancet. 2018;391(10116):125-132.
  3. Ferrer R, Martin-Loeches I, Phillips G, et al. Crit Care Med. 2014;42(8):1749-1755.
  4. Fonarow GC, Smith EE, Saver JL, et al. Circulation. 2011;123(7):750-758.
  5. Lee PMJ, Lee C, Rattner P, Wu X, Gershengorn H, Acquah S. Crit Care Med. 2015;43(6):1233-1238.
  6. Dumas RP, Vella MA, Maiga AW, et al. Moving the needle on time to resuscitation: An east prospective Multicenter Study of vascular access in hypotensive injured patients using Trauma Video Review. Journal of Trauma and Acute Care Surgery. 2023;Publish Ahead of Print. doi:10.1097/ta.0000000000003958 .
  7. Wang D, Deng L, Zhang R, Zhou Y, Zeng J, Jiang H. Efficacy of intraosseous access for trauma resuscitation: A systematic review and meta-analysis. World Journal of Emergency Surgery. 2023;18(1). doi:10.1186/s13017-023-00487-7
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