Cardiac Arrest: One of the Leading Causes of Mortality1
What could 10 seconds to vascular access mean to your cardiac arrest patients?
Key to Treatment: Rapid Delivery of Fluids and Medication
Clinicians need the fastest method of establishing vascular access—and IV access may be difficult or
impossible due to cardiovascular collapse and environmental challenges.
Success rates: IO > IV
Success rates for intraosseous vascular access have been shown to be superior to that of IV access
during cardiac arrest in comparative clinical studies.2,3
Return of Spontaneous Circulation (ROSC): IO = IV
Rates of return of spontaneous circulation (ROSC) in cardiac arrest have been shown to be similar for
patients that received IO and IV vascular access.2,3
Provides peripheral access with CVC performance4-7
Humeral IO access shown to facilitate rapid delivery of fluids and medications in cardiac arrest
and peri-arrest situations8,9
97% first-attempt access success rate10
Less than 1% serious complication rate11
Just three seconds to reach the heart with medication or fluid4,12
Lower insertion and infusion pain as compared to EZ-IO® System tibial
insertions13
While the articles support intraosseous vascular access indications, claims and
applications of Arrow® EZ-IO® Intraosseous Vascular Access System,
readers should consult a physician and product labeling for proper indications, contraindications,
warnings and precautions prior to use.
Potential complications may include local or systemic infection, hematoma, extravasations, or
other complications associated with percutaneous insertion of sterile devices.
Rx only
References:
Mozaffarian D, Benjamin EJ, Go AS, et al: on behalf of the American Heart Association
Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke
statistics—2015 update: a report from the American Heart Association. Circulation.
2015;131:e29–e322. DOI: 10.1161/CIR.0000000000000152.
Clemency B, Tanaka K, May P, et al. Intravenous vs. intraosseous access and return of spontaneous circulation during out of hospital cardiac
arrest. Am J Emerg Med. Oct 2016. doi: 10.1016/j.ajem.2016.10.052.
Bramlett E, Fales W, West B, LaBond V. Rate of return of spontaneous circulation in relation
to primary vascular access during out-of-hospital adult cardiac arrest. Ann Emerg Med. 2016;68(4S):S120.
Based on Adult Proximal Humerus EZ-IO® insertion data.
Compared to single lumen CVCs.
Hoskins SL, Zachariah BS, Copper N, Kramer GC. Comparison of intraosseous proximal humerus and sternal routes for drug
delivery during CPR. Circulation 2007; 116:II_993. Research sponsored by Teleflex Incorporated.
(preclinical study)
Hoskins SL, Nascimento P Jr., Lima RM, Espana-Tenorio, JM, Kramer GC. Pharmacokinetics of
intraosseous and central venous drug delivery during cardiopulmonary resuscitation.
Resuscitation 2011; doi:10.1016/j.resuscitation.2011.07.041. Research sponsored by Teleflex
Incorporated. (preclinical study)
Ross EM, Mapp J, Kharod CU. Time to epinephrine in out-of-hospital cardiac arrest: a
retrospective analysis of intraosseous versus intravenous access. Ann Emerg Med. 2016;68(4s):S61.
Lewis P, Wright C. Saving the critically injured trauma patient: a retrospective analysis of
1,000 uses of intraosseous access. Emerg Med J. 2014;31(9):784.
doi:10.1136/emermed-2014-203588.
Cooper BR, Mahoney PF, Hodgetts TJ, Mellor A. Intra-osseous access (EZ-IO®)
for resuscitation: UK military combat experience. J R Army Med Corps. 2007;153(4):314-316.
Teleflex Internal Data on File 2014.
Montez D, Puga T, Miller LJ, et al. Intraosseous infusions from the proximal humerus reach
the heart in less than 3 seconds in human volunteers. Annals of Emergency Medicine. 2015;66(4S):S47. Research sponsored by Teleflex Incorporated.
Philbeck TE, Miller LJ, Montez D, Puga T. Hurts so good; easing IO pain and pressure. JEMS. 2010;35(9):58-69. Research
sponsored by Teleflex Incorporated.
Teleflex, the Teleflex logo, Arrow, EZ-Connect, EZ-IO and EZ-Stabilizer are trademarks or registered
trademarks of Teleflex Incorporated or its affiliates, in the U.S. and/or other countries. MC-006531
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